Unlocking the Power of Neutrophils: A Deep Dive into Their Proteomes
Neutrophils—our body’s first line of defense—are the most abundant white blood cells and play a pivotal role in protecting against infection. These immune powerhouses act swiftly, deploying an arsenal of antimicrobial proteins, enzymes, and cytokines to combat invading pathogens. Their ability to regulate key immune functions such as adherence, phagocytosis, and chemotaxis makes them indispensable for host survival.
Traditionally, neutrophil research has relied on genetic, phenotypic, and biochemical analyses. However, cutting-edge advancements in mass spectrometry-based proteomics now enable an unprecedented level of insight into their immune responses. By comprehensively profiling neutrophil proteomes—including both cellular factors and secreted proteins—we can uncover critical mechanisms driving infection resolution and immune regulation.
In this methods publication, we introduce advanced methodologies for isolating and characterizing neutrophil proteomes. Join us as we explore how proteomics is revolutionizing our understanding of innate immunity and allowing for therapeutic discovery! Published in Current Protocols 2019
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